Mouse Anti-LGALS8 Recombinant Antibody (106.1) (CBMAB-G6327-LY)

Name: Mouse Anti-LGALS8 Recombinant Antibody (106.1)
SKU: CBMAB-G6327-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

106.1

Application

Immunogen

Recombinant protein corresponding to rat Galectin-8

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% BSA

Concentration

0.1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lectin, galactoside-binding, soluble, 8

Introduction

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Entrez Gene ID

3964

UniProt ID

O00214

Alternative Names

Gal-8; PCTA-1; PCTA1; Po66-CBP

Function

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878).
Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).
Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878).
Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324).
Also required to restrict infection of Picornaviridae viruses (PubMed:28077878).
Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).

Biological Process

Cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Lymphatic endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
XenophagyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasmic vesicle
Cytoplasm, cytosol

Zhong, J., & Wang, B. (2023). Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer. Acta Biochimica Polonica, 70(3), 551-559.

Wang, G., Shen, K., Xiao, J., Fan, H., Wang, Y., Liu, K., ... & Yang, L. (2023). Long non‐coding RNA LGALS8‐AS1 facilitates PLAGL2‐mediated malignant phenotypes in gastric cancer. The Journal of Gene Medicine, e3487.

Zhai, D., Li, T., Ye, R., Bi, J., Kuang, X., Shi, Y., ... & Lin, Y. (2021). LncRNA LGALS8-AS1 promotes breast cancer metastasis through miR-125b-5p/SOX12 feedback regulatory network. Frontiers in Oncology, 11, 711684.

Zhang, J., Qu, Y., Hou, T., Ge, W., & Zhang, S. (2021). ceRNA Network Analysis Shows That lncRNA LGALS8-AS1 Upregulates DCTPP1 To Promote Breast Cancer Progression Through Sponge miR-125b-5p.

Herkt, C. E., Caffrey, B. E., Surmann, K., Blankenburg, S., Gesell Salazar, M., Jung, A. L., ... & Schmeck, B. (2020). A microRNA network controls Legionella pneumophila replication in human macrophages via LGALS8 and MX1. MBio, 11(2), 10-1128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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