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LGALS8

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Full Name
lectin, galactoside-binding, soluble, 8
Function
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878).
Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).
Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878).
Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324).
Also required to restrict infection of Picornaviridae viruses (PubMed:28077878).
Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).
Biological Process
Cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Lymphatic endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
XenophagyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasmic vesicle
Cytoplasm, cytosol
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Anti-LGALS8 antibodies

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Recombinant Mouse Anti-LGALS8 Antibody (CBHb299) (CBMAB-Hb503-LY)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBHb299
Application*: FC, FuncS, Immuno assays
Datasheet SDS

Mouse Anti-LGALS8 Recombinant Antibody (CBFYA-0199) (CBMAB-X0280-FY)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYA-0199
Application*: F, FN, IA
Datasheet SDS

Mouse Anti-LGALS8 Recombinant Antibody (CBLG1-2376) (CBMAB-G6332-LY)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2376
Application*: IA, IC/IF, FN
Datasheet SDS

Mouse Anti-LGALS8 Recombinant Antibody (106.1) (CBMAB-G6327-LY)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 106.1
Application*: F
Datasheet SDS

Mouse Anti-LGALS8 Recombinant Antibody (210608) (CBMAB-G1129-LY)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 210608
Application*: WB
Datasheet SDS

Mouse Anti-LGALS8 Recombinant Antibody (CBYCL-276) (CBMAB-L0177-YC)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-276
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-LGALS8 Recombinant Antibody (3E5) (CBMAB-L1304-YJ)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E5
Application*: E, WB
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Mouse Anti-LGALS8 Recombinant Antibody (CBYJL-1533) (CBMAB-L1303-YJ)

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Target: LGALS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1533
Application*: F, FN
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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