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Mouse Anti-LGALS8 Recombinant Antibody (CBFYA-0199) (CBMAB-X0280-FY)

This product is mouse antibody that recognizes LGALS8. The antibody CBFYA-0199 can be used for immunoassay techniques such as: FC, FuncS, Immunoassay.
See all LGALS8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYA-0199
Antibody Isotype
IgG2a
Application
FC, FuncS, Immunoassay

Basic Information

Immunogen
Recombinant rat Galectin-8
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lectin, galactoside-binding, soluble, 8
Introduction
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains.
Entrez Gene ID
UniProt ID
Alternative Names
Gal-8; PCTA1; PCTA-1; Po66-CBP
Function
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878).
Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).
Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878).
Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324).
Also required to restrict infection of Picornaviridae viruses (PubMed:28077878).
Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).
Biological Process
Cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Lymphatic endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
XenophagyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasmic vesicle
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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