Human Recombinant LGALS8 protein, GST Tag (V2LY-0526-LY4250)

Name: Human Recombinant LGALS8 protein, GST Tag
SKU: V2LY-0526-LY4250
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant LGALS8 protein, GST Tag consist of Amino Acid: 1-317 and predicts a molecular mass of 62.7 kDa.

Molecule Mass

62.7 kDa

Sequence

Amino Acid: 1-317

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>70% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

lectin, galactoside-binding, soluble, 8

Function

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878).
Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).
Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878).
Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324).
Also required to restrict infection of Picornaviridae viruses (PubMed:28077878).
Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).

Biological Process

Cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Lymphatic endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
XenophagyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasmic vesicle
Cytoplasm, cytosol

Zhong, J., & Wang, B. (2023). Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer. Acta Biochimica Polonica, 70(3), 551-559.

Wang, G., Shen, K., Xiao, J., Fan, H., Wang, Y., Liu, K., ... & Yang, L. (2023). Long non‐coding RNA LGALS8‐AS1 facilitates PLAGL2‐mediated malignant phenotypes in gastric cancer. The Journal of Gene Medicine, e3487.

Zhai, D., Li, T., Ye, R., Bi, J., Kuang, X., Shi, Y., ... & Lin, Y. (2021). LncRNA LGALS8-AS1 promotes breast cancer metastasis through miR-125b-5p/SOX12 feedback regulatory network. Frontiers in Oncology, 11, 711684.

Zhang, J., Qu, Y., Hou, T., Ge, W., & Zhang, S. (2021). ceRNA Network Analysis Shows That lncRNA LGALS8-AS1 Upregulates DCTPP1 To Promote Breast Cancer Progression Through Sponge miR-125b-5p.

Herkt, C. E., Caffrey, B. E., Surmann, K., Blankenburg, S., Gesell Salazar, M., Jung, A. L., ... & Schmeck, B. (2020). A microRNA network controls Legionella pneumophila replication in human macrophages via LGALS8 and MX1. MBio, 11(2), 10-1128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LGALS8 protein (CAT#: V2LY-0526-LY4251)

Rat Recombinant LGALS8 protein, GST Tag (CAT#: V2LY-0526-LY9390)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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