Mouse Anti-LTBP2 Recombinant Antibody (CBYCL-531) (CBMAB-L0432-YC)

Name: Mouse Anti-LTBP2 Recombinant Antibody (CBYCL-531)
SKU: CBMAB-L0432-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-531

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

latent transforming growth factor beta binding protein 2

Introduction

LTBP2 belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.

Entrez Gene ID

4053

UniProt ID

Q14767

Alternative Names

C14orf141; GLC3D; LTBP3; MSPKA; MSTP031; WMS3

Function

May play an integral structural role in elastic-fiber architectural organization and/or assembly.

Biological Process

Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Protein targetingManual Assertion Based On ExperimentTAS:ProtInc
Supramolecular fiber organizationManual Assertion Based On ExperimentIMP:MGI
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted, extracellular space, extracellular matrix

Involvement in disease

Glaucoma 3, primary congenital, D (GLC3D):
An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma (MSPKA):
A rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens, and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
Weill-Marchesani syndrome 3 (WMS3):
Weill-Marchesani syndrome 3 (WMS3)

PTM

N-Glycosylated.
Contains hydroxylated asparagine residues.

Nishiura, K., Yokokawa, T., Misaka, T., Ichimura, S., Tomita, Y., Miura, S., ... & Takeishi, Y. (2023). Prognostic role of circulating LTBP-2 in patients with dilated cardiomyopathy: a novel biomarker reflecting extracellular matrix LTBP-2 accumulation. Canadian Journal of Cardiology.

Bodmer, N. K., Knutsen, R. H., Roth, R. A., Castile, R. M., Brodt, M. D., Gierasch, C. M., ... & Ornitz, D. M. (2023). Multi‐organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2). Developmental Dynamics.

Zhang, X., Tian, C., Cheng, J., Mao, W., Li, M., & Chen, M. (2022). LTBP2 inhibits prostate cancer progression and metastasis via the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 24(3), 1-16.

Zhao, J., Liu, X., Cong, K., Chang, J., Shan, H., & Zheng, Y. (2022). The prognostic significance of LTBP2 for malignant tumors: Evidence based on 11 observational studies. Medicine, 101(17).

Boucherat, O., Yokokawa, T., Krishna, V., Kalyana-Sundaram, S., Martineau, S., Breuils-Bonnet, S., ... & Bonnet, S. (2022). Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nature Cardiovascular Research, 1(8), 748-760.

Wang, T., Zhou, Z., Wang, C., Qin, Y., Wu, L., Hu, B., ... & Huang, M. (2022). LTBP2 knockdown promotes ferroptosis in gastric cancer cells through p62-Keap1-Nrf2 pathway. BioMed Research International, 2022.

Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R. P., Kumra, H., ... & Bassnett, S. (2021). Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biology, 95, 15-31.

Wang, J., Jiang, C., Li, N., Wang, F., Xu, Y., Shen, Z., ... & He, C. (2020). The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway. Cell death & disease, 11(8), 682.

Pang, X. F., Lin, X., Du, J. J., & Zeng, D. Y. (2020). LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Acta Physiologica, 228(3), e13377.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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