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Mouse Anti-LTBP2 Recombinant Antibody (CBYCL-533) (CBMAB-L0434-YC)

Provided herein is a Mouse monoclonal antibody against Cattle LTBP2. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all LTBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle
Clone
CBYCL-533
Antibody Isotype
IgG
Application
ELISA, IP, WB

Basic Information

Specificity
Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
latent transforming growth factor beta binding protein 2
Introduction
LTBP2 may play an integral structural role in elastic-fiber architectural organization and/or assembly. x may be involved in the assembly, secretion and targeting of TGF- beta to sites at which it is stored and/or activated. x may play critical roles in controlling and directing the activity of TGF-beta. LTBP2 may have a structural role in the extracellular matrix (ECM).
Entrez Gene ID
281905
UniProt ID
Q28019
Alternative Names
C14orf141; GLC3D; LTBP3; MSPKA; MSTP031; WMS3
Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Biological Process
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Protein targetingManual Assertion Based On ExperimentTAS:ProtInc
Supramolecular fiber organizationManual Assertion Based On ExperimentIMP:MGI
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Glaucoma 3, primary congenital, D (GLC3D):
An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma (MSPKA):
A rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens, and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
Weill-Marchesani syndrome 3 (WMS3):
Weill-Marchesani syndrome 3 (WMS3)
PTM
N-Glycosylated.
Contains hydroxylated asparagine residues.

Nishiura, K., Yokokawa, T., Misaka, T., Ichimura, S., Tomita, Y., Miura, S., ... & Takeishi, Y. (2023). Prognostic role of circulating LTBP-2 in patients with dilated cardiomyopathy: a novel biomarker reflecting extracellular matrix LTBP-2 accumulation. Canadian Journal of Cardiology.

Bodmer, N. K., Knutsen, R. H., Roth, R. A., Castile, R. M., Brodt, M. D., Gierasch, C. M., ... & Ornitz, D. M. (2023). Multi‐organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2). Developmental Dynamics.

Zhang, X., Tian, C., Cheng, J., Mao, W., Li, M., & Chen, M. (2022). LTBP2 inhibits prostate cancer progression and metastasis via the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 24(3), 1-16.

Zhao, J., Liu, X., Cong, K., Chang, J., Shan, H., & Zheng, Y. (2022). The prognostic significance of LTBP2 for malignant tumors: Evidence based on 11 observational studies. Medicine, 101(17).

Boucherat, O., Yokokawa, T., Krishna, V., Kalyana-Sundaram, S., Martineau, S., Breuils-Bonnet, S., ... & Bonnet, S. (2022). Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nature Cardiovascular Research, 1(8), 748-760.

Wang, T., Zhou, Z., Wang, C., Qin, Y., Wu, L., Hu, B., ... & Huang, M. (2022). LTBP2 knockdown promotes ferroptosis in gastric cancer cells through p62-Keap1-Nrf2 pathway. BioMed Research International, 2022.

Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R. P., Kumra, H., ... & Bassnett, S. (2021). Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biology, 95, 15-31.

Wang, J., Jiang, C., Li, N., Wang, F., Xu, Y., Shen, Z., ... & He, C. (2020). The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway. Cell death & disease, 11(8), 682.

Pang, X. F., Lin, X., Du, J. J., & Zeng, D. Y. (2020). LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Acta Physiologica, 228(3), e13377.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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