Sign in or Register   Sign in or Register
  |  

Mouse Anti-LTBP2 Recombinant Antibody (5D7) (CBMAB-A5118-LY)

The product is antibody recognizes LTBP2. The antibody 5D7 immunoassay techniques such as: WB, ELISA.
See all LTBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5D7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
LTBP2 (NP_000419, 1709 a.a. ~ 1818 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
latent transforming growth factor beta binding protein 2
Introduction
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq]
Entrez Gene ID
4053
UniProt ID
Q14767
Alternative Names
C14orf141; LTBP3; MSTP031
Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Biological Process
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Protein targetingManual Assertion Based On ExperimentTAS:ProtInc
Supramolecular fiber organizationManual Assertion Based On ExperimentIMP:MGI
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Glaucoma 3, primary congenital, D (GLC3D):
An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma (MSPKA):
A rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens, and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
Weill-Marchesani syndrome 3 (WMS3):
Weill-Marchesani syndrome 3 (WMS3)
PTM
N-Glycosylated.
Contains hydroxylated asparagine residues.

Nishiura, K., Yokokawa, T., Misaka, T., Ichimura, S., Tomita, Y., Miura, S., ... & Takeishi, Y. (2023). Prognostic role of circulating LTBP-2 in patients with dilated cardiomyopathy: a novel biomarker reflecting extracellular matrix LTBP-2 accumulation. Canadian Journal of Cardiology.

Bodmer, N. K., Knutsen, R. H., Roth, R. A., Castile, R. M., Brodt, M. D., Gierasch, C. M., ... & Ornitz, D. M. (2023). Multi‐organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2). Developmental Dynamics.

Zhang, X., Tian, C., Cheng, J., Mao, W., Li, M., & Chen, M. (2022). LTBP2 inhibits prostate cancer progression and metastasis via the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 24(3), 1-16.

Zhao, J., Liu, X., Cong, K., Chang, J., Shan, H., & Zheng, Y. (2022). The prognostic significance of LTBP2 for malignant tumors: Evidence based on 11 observational studies. Medicine, 101(17).

Boucherat, O., Yokokawa, T., Krishna, V., Kalyana-Sundaram, S., Martineau, S., Breuils-Bonnet, S., ... & Bonnet, S. (2022). Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nature Cardiovascular Research, 1(8), 748-760.

Wang, T., Zhou, Z., Wang, C., Qin, Y., Wu, L., Hu, B., ... & Huang, M. (2022). LTBP2 knockdown promotes ferroptosis in gastric cancer cells through p62-Keap1-Nrf2 pathway. BioMed Research International, 2022.

Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R. P., Kumra, H., ... & Bassnett, S. (2021). Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biology, 95, 15-31.

Wang, J., Jiang, C., Li, N., Wang, F., Xu, Y., Shen, Z., ... & He, C. (2020). The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway. Cell death & disease, 11(8), 682.

Pang, X. F., Lin, X., Du, J. J., & Zeng, D. Y. (2020). LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Acta Physiologica, 228(3), e13377.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LTBP2 Recombinant Antibody (5D7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare