Mouse Ltbp2 ELISA Kit (V2LY-0626-LY1470)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.013 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
195.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
latent transforming growth factor beta binding protein 2
Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Biological Process
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Protein targetingManual Assertion Based On ExperimentTAS:ProtInc
Supramolecular fiber organizationManual Assertion Based On ExperimentIMP:MGI
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Glaucoma 3, primary congenital, D (GLC3D):
An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma (MSPKA):
A rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens, and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
Weill-Marchesani syndrome 3 (WMS3):
Weill-Marchesani syndrome 3 (WMS3)
PTM
N-Glycosylated.
Contains hydroxylated asparagine residues.

Nishiura, K., Yokokawa, T., Misaka, T., Ichimura, S., Tomita, Y., Miura, S., ... & Takeishi, Y. (2023). Prognostic role of circulating LTBP-2 in patients with dilated cardiomyopathy: a novel biomarker reflecting extracellular matrix LTBP-2 accumulation. Canadian Journal of Cardiology.

Bodmer, N. K., Knutsen, R. H., Roth, R. A., Castile, R. M., Brodt, M. D., Gierasch, C. M., ... & Ornitz, D. M. (2023). Multi‐organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2). Developmental Dynamics.

Zhang, X., Tian, C., Cheng, J., Mao, W., Li, M., & Chen, M. (2022). LTBP2 inhibits prostate cancer progression and metastasis via the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 24(3), 1-16.

Zhao, J., Liu, X., Cong, K., Chang, J., Shan, H., & Zheng, Y. (2022). The prognostic significance of LTBP2 for malignant tumors: Evidence based on 11 observational studies. Medicine, 101(17).

Boucherat, O., Yokokawa, T., Krishna, V., Kalyana-Sundaram, S., Martineau, S., Breuils-Bonnet, S., ... & Bonnet, S. (2022). Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nature Cardiovascular Research, 1(8), 748-760.

Wang, T., Zhou, Z., Wang, C., Qin, Y., Wu, L., Hu, B., ... & Huang, M. (2022). LTBP2 knockdown promotes ferroptosis in gastric cancer cells through p62-Keap1-Nrf2 pathway. BioMed Research International, 2022.

Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R. P., Kumra, H., ... & Bassnett, S. (2021). Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biology, 95, 15-31.

Wang, J., Jiang, C., Li, N., Wang, F., Xu, Y., Shen, Z., ... & He, C. (2020). The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway. Cell death & disease, 11(8), 682.

Pang, X. F., Lin, X., Du, J. J., & Zeng, D. Y. (2020). LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Acta Physiologica, 228(3), e13377.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Ltbp2 ELISA Kit (CAT#: V2LY-0626-LY1284)

Human LTBP2 ELISA Kit (CAT#: V2LY-0626-LY842)

Related Products

Human LTBP2 ELISA Kit (CAT#: V2LY-0626-LY842)

Rat Ltbp2 ELISA Kit (CAT#: V2LY-0626-LY1284)

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Mouse Anti-LTBP2 Recombinant Antibody (CBYCL-531) (CAT#: CBMAB-L0432-YC)

Mouse Anti-LTBP2 Recombinant Antibody (5D7) (CAT#: CBMAB-A5118-LY)

Mouse Anti-LTBP2 Recombinant Antibody (CBYCL-533) (CAT#: CBMAB-L0434-YC)

Isotype control

For research use only. Not intended for any clinical use.

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