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Mouse Anti-TNNI2 Recombinant Antibody (CBT4469) (V2LY-0625-LY2651)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4469
Antibody Isotype
IgG1
Application
IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human TNNI2 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Troponin I Type 2 (Skeletal, Fast)
Entrez Gene ID
7136
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process cardiac muscle contraction Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of muscle contraction Source:Ensembl
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleus
troponin complex
Involvement in disease
Arthrogryposis, distal, 2B1 (DA2B1):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B1 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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