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Mouse Anti-TNNI2 Recombinant Antibody (CBYJT-4071) (CBMAB-T3487-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNNI2 (Troponin I2, Fast Skeletal Type). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TNNI2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4071
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Human
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.1% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Troponin I Type 2 (Skeletal, Fast)
Introduction
TNNI2 is a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may function in regulation of smooth muscle function. In addition to muscle tissues, TNNI2 is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it plays a role as a co-activator of estrogen receptor-related receptor alpha. TNNI2 also suppresses tumor growth in human ovarian carcinoma. Mutations in TNNI2 cause myopathy and distal arthrogryposis type 2B.
Entrez Gene ID
7136
UniProt ID
P48788
Alternative Names
Troponin I2, Fast Skeletal Type; Troponin I, Fast-Twitch Skeletal Muscle Isoform; Troponin I Type 2 (Skeletal, Fast); Troponin I, Fast-Twitch Isoform; Troponin I, Skeletal, Fast; Troponin I Fast Twitch 2; Arthrogryposis Multiplex Congenita, Distal, Type 2B
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process cardiac muscle contraction Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of muscle contraction Source:Ensembl
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleus
troponin complex
Involvement in disease
Arthrogryposis, distal, 2B1 (DA2B1):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B1 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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