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Mouse Anti-ZBTB16 Recombinant Antibody (CBT1040) (V2LY-0625-LY3088)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT1040
Antibody Isotype
IgG
Application
WB, IF, ICC, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human PLZF expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
IF1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Zinc Finger And BTB Domain Containing 16
Entrez Gene ID
7704
Function
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566).
Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654).
May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Biological Process
Biological Process anterior/posterior pattern specification Source:Ensembl
Biological Process apoptotic process Source:UniProtKB1 Publication
Biological Process cartilage development Source:UniProtKB1 Publication
Biological Process cell population proliferation Source:Ensembl
Biological Process central nervous system development Source:UniProtKBBy Similarity
Biological Process embryonic digit morphogenesis Source:Ensembl
Biological Process embryonic hindlimb morphogenesis Source:Ensembl
Biological Process embryonic pattern specification Source:Ensembl
Biological Process forelimb morphogenesis Source:Ensembl
Biological Process hemopoiesis Source:UniProtKB1 Publication
Biological Process male germ-line stem cell asymmetric division Source:Ensembl
Biological Process mesonephros development Source:UniProtKBBy Similarity
Biological Process myeloid cell differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of myeloid cell differentiation Source:UniProtKBBy Similarity
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process ossification involved in bone maturation Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process positive regulation of cartilage development Source:UniProtKB1 Publication
Biological Process positive regulation of chondrocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of NK T cell differentiation Source:Ensembl
Biological Process positive regulation of ossification Source:UniProtKB1 Publication
Biological Process protein localization to nucleus Source:Ensembl
Biological Process protein ubiquitination Source:UniProtKB-UniPathway
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Nucleus, nuclear body
Involvement in disease
Skeletal defects, genital hypoplasia, and impaired intellectual development (SGYMR):
A disorder characterized by intellectual disability, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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