Mouse Anti-ZBTB16 Recombinant Antibody (3A7) (CBMAB-Z0079-WJ)

Zinc Finger And BTB Domain Containing 16

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

PLZF; ZNF145

Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566).
Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654).
May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).

Biological Process anterior/posterior pattern specification Source:Ensembl
Biological Process apoptotic process Source:UniProtKB1 Publication
Biological Process cartilage development Source:UniProtKB1 Publication
Biological Process cell population proliferation Source:Ensembl
Biological Process central nervous system development Source:UniProtKBBy Similarity
Biological Process embryonic digit morphogenesis Source:Ensembl
Biological Process embryonic hindlimb morphogenesis Source:Ensembl
Biological Process embryonic pattern specification Source:Ensembl
Biological Process forelimb morphogenesis Source:Ensembl
Biological Process hemopoiesis Source:UniProtKB1 Publication
Biological Process male germ-line stem cell asymmetric division Source:Ensembl
Biological Process mesonephros development Source:UniProtKBBy Similarity
Biological Process myeloid cell differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of myeloid cell differentiation Source:UniProtKBBy Similarity
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process ossification involved in bone maturation Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process positive regulation of cartilage development Source:UniProtKB1 Publication
Biological Process positive regulation of chondrocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of NK T cell differentiation Source:Ensembl
Biological Process positive regulation of ossification Source:UniProtKB1 Publication
Biological Process protein localization to nucleus Source:Ensembl
Biological Process protein ubiquitination Source:UniProtKB-UniPathway
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Nucleus
Nucleus, nuclear body

Skeletal defects, genital hypoplasia, and impaired intellectual development (SGYMR):
A disorder characterized by intellectual disability, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.