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Mouse Anti-ZBTB16 Recombinant Antibody (5B3) (CBMAB-Z0075-WJ)

This product is a mouse antibody that recognizes ZBTB16. The antibody 5B3 can be used for immunoassay techniques such as: ELISA, ICC, IF, IHC-P, WB.
See all ZBTB16 antibodies
Published Data
Fig.1 Endogenous coimmunoprecipitation of PLZF and SIRT1.
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Fig.2 The nuclear localization pattern of PLZF (and indicated conditions) was analyzed in 293T cells transfected with PLZF alone (PLZF) by indirect immunofluorescence and confocal microscopy, as reported previously, punctate nuclear distribution of wild-type PLZF was observed (PLZF).
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5B3
Antibody Isotype
IgG1
Application
ELISA, ICC, IF, IHC-P, WB

Basic Information

Immunogen
Purified recombinant fragment of human ZBTB16 expressed in E. coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
Zinc Finger And BTB Domain Containing 16
Introduction
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Entrez Gene ID
7704
UniProt ID
Q05516
Alternative Names
PLZF; ZNF145
Function
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566).
Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654).
May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Biological Process
Biological Process anterior/posterior pattern specification Source:Ensembl
Biological Process apoptotic process Source:UniProtKB1 Publication
Biological Process cartilage development Source:UniProtKB1 Publication
Biological Process cell population proliferation Source:Ensembl
Biological Process central nervous system development Source:UniProtKBBy Similarity
Biological Process embryonic digit morphogenesis Source:Ensembl
Biological Process embryonic hindlimb morphogenesis Source:Ensembl
Biological Process embryonic pattern specification Source:Ensembl
Biological Process forelimb morphogenesis Source:Ensembl
Biological Process hemopoiesis Source:UniProtKB1 Publication
Biological Process male germ-line stem cell asymmetric division Source:Ensembl
Biological Process mesonephros development Source:UniProtKBBy Similarity
Biological Process myeloid cell differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of myeloid cell differentiation Source:UniProtKBBy Similarity
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process ossification involved in bone maturation Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process positive regulation of cartilage development Source:UniProtKB1 Publication
Biological Process positive regulation of chondrocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of NK T cell differentiation Source:Ensembl
Biological Process positive regulation of ossification Source:UniProtKB1 Publication
Biological Process protein localization to nucleus Source:Ensembl
Biological Process protein ubiquitination Source:UniProtKB-UniPathway
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Nucleus, nuclear body
Involvement in disease
Skeletal defects, genital hypoplasia, and impaired intellectual development (SGYMR):
A disorder characterized by intellectual disability, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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