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ACAN

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Full Name
Aggrecan
Function
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Biological Process
Cell adhesion
Central nervous system development
Extracellular matrix organization
Keratan sulfate biosynthetic process
Keratan sulfate catabolic process
Proteolysis
Skeletal system development
Cellular Location
Extracellular matrix
Involvement in disease
Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts.
An autosomal dominant disease characterized by short stature, advanced bone maturation, early-onset osteoarthritis, and mild dysmorphic features consisting of midface hypoplasia, brachydactyly, broad great toes, and lumbar lordosis. Other features include intervertebral disk disease and osteochondritis dissecans. Osteochondritis dissecans is defined as a separation of cartilage and subchondral bone from the surrounding tissue.
PTM
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
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Anti-ACAN antibodies

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Mouse Anti-ACAN Recombinant Antibody (V2-179190) (CBMAB-A0447-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-179190
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ACAN Recombinant Antibody (V2-179208) (CBMAB-A0466-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179208
Application*: WB, IH, IP
Datasheet SDS

Mouse Anti-ACAN Recombinant Antibody (V2-179203) (CBMAB-A0461-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat, Cat
Clone: V2-179203
Application*: WB, IH, IC, IF, IP
Datasheet SDS

Mouse Anti-ACAN Recombinant Antibody (V2-179199) (CBMAB-A0456-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: V2-179199
Application*: F, IH, WB, E, IP
Datasheet SDS

Mouse Anti-ACAN Recombinant Antibody (V2-179196) (CBMAB-A0453-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Cattle
Clone: V2-179196
Application*: WB, E, IH, P, C
Datasheet SDS

Mouse Anti-ACAN Recombinant Antibody (V2-179188) (CBMAB-A0445-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179188
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-ACAN Monoclonal Antibody (V2-5181) (CBMAB-0929-YC)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: V2-5181
Application*: E, C, IP, P, WB
Datasheet SDS

Mouse Anti-ACAN Recombinant Antibody (V2-12499) (CBMAB-0989-CN)

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Sheep, Rabbit, Horse, Guinea pig, Cattle, Cat, Dog, Pig
Clone: V2-12499
Application*: E, C, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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