ACP6

This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]

Full Name

Acid Phosphatase 6, Lysophosphatidic

Function

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.

Biological Process

Dephosphorylation
Hematopoietic progenitor cell differentiation
Lysobisphosphatidic acid metabolic process
Phosphatidic acid biosynthetic process
Phospholipid metabolic process

Cellular Location

Mitochondrion