ARHGAP4

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

Rho GTPase activating protein 4

Function

Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

Biological Process

Cytoskeleton organization Source: ProtInc
Negative regulation of axon extension Source: Ensembl
Negative regulation of cell migration Source: GO_Central
Negative regulation of fibroblast migration Source: Ensembl
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: ProtInc

Cellular Location

Cytoplasm. Just below the plasma membrane.