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Mouse Anti-ARHGAP4 Recombinant Antibody (3F7) (CBMAB-A0456-LY)

The product is antibody recognizes ARHGAP4. The antibody 3F7 immunoassay techniques such as: WB, ELISA.
See all ARHGAP4 antibodies
Published Data
Fig. 1 Western blot analysis of example caspase substrates during staurosporine treatment.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ARHGAP4 (AAH52303, 881 a.a. ~ 986 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rho GTPase activating protein 4
Introduction
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
393
UniProt ID
P98171
Alternative Names
C1; KIAA0131; RGC1; RhoGAP4; p115
Function
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Biological Process
Cytoskeleton organization Source: ProtInc
Negative regulation of axon extension Source: Ensembl
Negative regulation of cell migration Source: GO_Central
Negative regulation of fibroblast migration Source: Ensembl
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: ProtInc
Cellular Location
Cytoplasm. Just below the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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