ARHGEF6

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]

Rac/Cdc42 Guanine Nucleotide Exchange Factor 6

Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Apoptotic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome

Lamellipodium