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ARHGEF6

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]

Full Name

Rac/Cdc42 Guanine Nucleotide Exchange Factor 6

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Biological Process

Apoptotic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome

Cellular Location

Lamellipodium

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Anti-ARHGEF6 antibodies

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Rabbit Anti-ARHGEF6 Recombinant Antibody (C23D2) (CBMAB-CP0347-LY)

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Target: ARHGEF6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: C23D2

Application*: WB, IF

Mouse Anti-ARHGEF6 Recombinant Antibody (2E5) (CBMAB-A0472-LY)

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Target: ARHGEF6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E5

Application*: WB, E

ARHGEF6 Matched Antibody Pair (106) (APMAB-106LY)

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Target: ARHGEF6

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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