ARHGEF6
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
Full Name
Rac/Cdc42 Guanine Nucleotide Exchange Factor 6
Function
Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Biological Process
Apoptotic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Lamellipodium
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Anti-ARHGEF6 antibodies
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Target: ARHGEF6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: C23D2
Application*: WB, IF
Target: ARHGEF6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E5
Application*: WB, E
Target: ARHGEF6
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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