ARHGEF6 Matched Antibody Pair (106) (APMAB-106LY)

This antibody pair set can be used for detecting and quantifying protein level of human ARHGEF6.
See all ARHGEF6 antibodies

Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-ARHGEF6 monoclonal antibody, 100 ug

Detection Antibody

Anti-ARHGEF6 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]

Alternative Names

Rac/Cdc42 Guanine Nucleotide Exchange Factor 6; Rac/Cdc42 Guanine Nucleotide Exchange Factor (GEF) 6; Rac/Cdc42 Guanine Exchange Factor (GEF) 6; Rho Guanine Nucleotide Exchange Factor 6; PAK-Interacting Exchange Factor, Alpha; Alpha-PIX; Cool-2; COOL2;

Entrez Gene ID

9459

UniProt ID

Q15052

References

Mamula, D., Korthals, M., Hradsky, J., Gottfried, A., Fischer, K. D., & Tedford, K. (2021). Arhgef6 (alpha‐PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence. Journal of Leukocyte Biology.

Khimsuriya, Y. M., & Chauhan, J. B. (2018). Pathogenic predictions of non-synonymous variants and their impacts: A computational assessment of ARHGEF6 gene. Egyptian Journal of Medical Human Genetics, 19(4), 333-344.

Pratt-Hyatt, M., Haeusler, R. A., Yuen, K. C., & Shaw, W. (2018). A Single Nucleotide Polymorphism in the ARHGEF6 Gene is Associated with Increased Risk for Autism Spectrum Disorder. Hereditary Genetics, 7(2), 117-127.

Zhu, C., Cheng, C., Wang, Y., Muhammad, W., Liu, S., Zhu, W., ... & Chai, R. (2018). Loss of ARHGEF6 causes hair cell stereocilia deficits and hearing loss in mice. Frontiers in molecular neuroscience, 11, 362.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ARHGEF6 Recombinant Antibody (2E5)

Rabbit Anti-ARHGEF6 Recombinant Antibody (C23D2)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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