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Mouse Anti-ARHGEF6 Recombinant Antibody (2E5) (CBMAB-A0472-LY)

The product is antibody recognizes ARHGEF6. The antibody 2E5 immunoassay techniques such as: WB, ELISA.
See all ARHGEF6 antibodies
Published Data
Fig.1 Independence of GBF1 in the translocation of PAK1, αPIX, and Gβγ to the leading edges.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ARHGEF6 (AAH39856.1, 61 a.a. ~ 175 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rac/Cdc42 Guanine Nucleotide Exchange Factor 6
Introduction
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq]
Entrez Gene ID
9459
UniProt ID
Q15052
Alternative Names
COOL2; Cool-2; KIAA0006; MRX46; PIXA; alpha-PIX; alphaPIX
Function
Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Biological Process
Apoptotic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Lamellipodium
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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