Mouse Anti-ARHGEF6 Recombinant Antibody (2E5) (CBMAB-A0472-LY)

Name: Mouse Anti-ARHGEF6 Recombinant Antibody (2E5)
SKU: CBMAB-A0472-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E5

Application

WB, ELISA

Immunogen

ARHGEF6 (AAH39856.1, 61 a.a. ~ 175 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Rac/Cdc42 Guanine Nucleotide Exchange Factor 6

Introduction

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq]

Entrez Gene ID

9459

UniProt ID

Q15052

Alternative Names

COOL2; Cool-2; KIAA0006; MRX46; PIXA; alpha-PIX; alphaPIX

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Biological Process

Apoptotic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
JNK cascade Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome

Cellular Location

Lamellipodium

Mamula, D., Korthals, M., Hradsky, J., Gottfried, A., Fischer, K. D., & Tedford, K. (2021). Arhgef6 (alpha‐PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence. Journal of Leukocyte Biology.

Khimsuriya, Y. M., & Chauhan, J. B. (2018). Pathogenic predictions of non-synonymous variants and their impacts: A computational assessment of ARHGEF6 gene. Egyptian Journal of Medical Human Genetics, 19(4), 333-344.

Pratt-Hyatt, M., Haeusler, R. A., Yuen, K. C., & Shaw, W. (2018). A Single Nucleotide Polymorphism in the ARHGEF6 Gene is Associated with Increased Risk for Autism Spectrum Disorder. Hereditary Genetics, 7(2), 117-127.

Zhu, C., Cheng, C., Wang, Y., Muhammad, W., Liu, S., Zhu, W., ... & Chai, R. (2018). Loss of ARHGEF6 causes hair cell stereocilia deficits and hearing loss in mice. Frontiers in molecular neuroscience, 11, 362.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

ARHGEF6 Matched Antibody Pair (106) (CAT#: APMAB-106LY)

Related Products

Rabbit Anti-ARHGEF6 Recombinant Antibody (C23D2) (CAT#: CBMAB-CP0347-LY)

ARHGEF6 Matched Antibody Pair (106) (CAT#: APMAB-106LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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