ATP23

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.

ATP23 Metallopeptidase And ATP Synthase Assembly Factor Homolog

Double-strand break repair via nonhomologous end joining Source: UniProtKB
Mitochondrial protein processing Source: GO_Central
Mitochondrial proton-transporting ATP synthase complex assembly Source: GO_Central

Cytosol; Extrinsic component of mitochondrial inner membrane; DNA-dependent protein kinase-DNA ligase 4 complex; Plasma membrane; Cell junction; Intracellular membrane-bounded organelle