BTG2

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq]

Full Name

BTG family, member 2

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity).
Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Associative learning Source: Ensembl
Cellular response to DNA damage stimulus Source: MGI
Central nervous system neuron development Source: Ensembl
Dentate gyrus development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
DNA repair Source: ProtInc
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Negative regulation of neural precursor cell proliferation Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of translation Source: UniProtKB
Neuron projection development Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: MGI
Protein methylation Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to peptide hormone Source: Ensembl
Skeletal muscle cell differentiation Source: Ensembl

Cellular Location

Cytosol; Extracellular exosome; Nucleus; Cytoplasm

PTM

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.