Mouse Anti-BTG2 Recombinant Antibody (1B8) (CBMAB-A0900-LY)

Name: Mouse Anti-BTG2 Recombinant Antibody (1B8)
SKU: CBMAB-A0900-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B8

Application

WB, E

Immunogen

BTG2 (NP_006754, 59 a.a. ~ 158 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

BTG family, member 2

Introduction

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq]

Entrez Gene ID

7832

UniProt ID

P78543

Alternative Names

MGC126063; MGC126064; PC3; TIS21

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity).
Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Associative learning Source: Ensembl
Cellular response to DNA damage stimulus Source: MGI
Central nervous system neuron development Source: Ensembl
Dentate gyrus development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
DNA repair Source: ProtInc
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Negative regulation of neural precursor cell proliferation Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of translation Source: UniProtKB
Neuron projection development Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: MGI
Protein methylation Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to peptide hormone Source: Ensembl
Skeletal muscle cell differentiation Source: Ensembl

Cellular Location

Cytosol; Extracellular exosome; Nucleus; Cytoplasm

PTM

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.

He, G., Pang, R., Han, J., Jia, J., Ding, Z., Bi, W., ... & Sun, Y. (2021). TINCR inhibits the proliferation and invasion of laryngeal squamous cell carcinoma by regulating miR-210/BTG2. BMC cancer, 21(1), 1-16.

Hoffman, M., Takizawa, A., Jensen, E., Schilling, R., Grzybowski, M., Geurts, A. M., & Dwinell, M. R. (2020). Abstract P124: Blood Pressure Characterization In Btg2 Mutant Rat. Hypertension, 76(Suppl_1), AP124-AP124.

Zhang, S. J., Ma, J., Wu, J. C., Hao, Z. Z., Zhang, Y. A., & Zhang, Y. J. (2020). Circular RNA circCRIM1 suppresses lung adenocarcinoma cell migration, invasion, EMT, and glycolysis through regulating miR-125b-5p/BTG2 axis. Eur Rev Med Pharmacol Sci, 24(7), 3761-3774.

Shuai, Y., Ma, Z., Liu, W., Yu, T., Yan, C., Jiang, H., ... & Shu, Y. (2020). TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2. Molecular cancer, 19(1), 1-20.

Hu, D., Gu, Y., Wu, D., Zhang, J., Li, Q., Luo, J., ... & Zhu, B. (2020). Icariside II protects cardiomyocytes from hypoxia‑induced injury by upregulating the miR‑7‑5p/BTG2 axis and activating the PI3K/Akt signaling pathway. International Journal of Molecular Medicine, 46(4), 1453-1465.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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