C1D

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined. [provided by RefSeq]
Full Name
nuclear DNA-binding protein
Function
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Maturation of 5.8S rRNA Source: UniProtKB
Regulation of gene expression Source: GO_Central
rRNA processing Source: Reactome
Cellular Location
Nucleus; Nucleolus; Cytoplasm. EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738).
PTM
Phosphorylated by PRKDC.
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Anti-C1D antibodies

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Rabbit Anti-C1D Recombinant Antibody (004) (CBMAB-C1502-LY)

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Target: C1D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 004
Application*: WB
Datasheet SDS

Rabbit Anti-C1D Recombinant Antibody (042) (CBMAB-C1760-LY)

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Target: C1D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 042
Application*: E
Datasheet SDS

Mouse Anti-C1D Recombinant Antibody (02) (CBMAB-C1648-LY)

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Target: C1D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 02
Application*: E
Datasheet SDS

Human Recombinant C1D protein, GST Tag (V2LY-0526-LY2452)

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Target: C1D
Expressed Host: E. coli
Sequence: Amino Acid: 1-141
Tag: GST Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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