C1GALT1

The common core 1 O-glycan structure Gal-beta-1-3GalNAc-R is a precursor for many extended mucin-type O-glycan structures in animal cell surface and secreted glycoproteins. Core 1 is synthesized by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R by core 1 beta-3-galactosyltransferase (C1GALT1) (Ju et al., 2002 [PubMed 11677243]).[supplied by OMIM

Full Name

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

Function

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.

Biological Process

Angiogenesis Source: UniProtKB
Cell differentiation Source: UniProtKB-KW
Kidney development Source: UniProtKB
O-glycan processing Source: Reactome
O-glycan processing, core 1 Source: GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-6 aa
Helical: 7-29 aa
Lumenal: 30-363 aa

Anti-C1GALT1 antibodies

Mouse Anti-C1GALT1 Recombinant Antibody (CBFYC-0594) (CBMAB-C0648-FY)

Datasheet

SDS

Target: C1GALT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-0594

Application*: E, IF, P, WB, IP

Mouse Anti-C1GALT1 Recombinant Antibody (1F1) (CBMAB-C3996-LY)

Datasheet

SDS

Target: C1GALT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F1

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)