CD24

CD24 (CD24 Molecule) is a protein coding gene. Diseases associated with CD24 include Multiple Sclerosis. Among its related pathways are L1CAM interactions and Developmental Biology. Gene Ontology annotations related to this gene include protein kinase binding and carbohydrate binding.

Full Name

CD24 Molecule

Function

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396).
In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

Biological Process

B cell receptor transport into membrane raft Source: UniProtKB
Cell activation Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell migration Source: UniProtKB
Chemokine receptor transport out of membrane raft Source: UniProtKB
Cholesterol homeostasis Source: UniProtKB
Glomerular parietal epithelial cell differentiation Source: UniProtKB
Glomerular visceral epithelial cell differentiation Source: UniProtKB
Immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of transforming growth factor beta3 production Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
Regulation of cytokine-mediated signaling pathway Source: UniProtKB
Regulation of epithelial cell differentiation Source: UniProtKB
Regulation of MAPK cascade Source: UniProtKB
Regulation of phosphorylation Source: UniProtKB
Respiratory burst Source: UniProtKB
Response to estrogen Source: UniProtKB
Response to hypoxia Source: UniProtKB
Response to molecule of bacterial origin Source: UniProtKB
T cell costimulation Source: UniProtKB
Wnt signaling pathway Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Multiple sclerosis (MS): A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

PTM

Extensively O-glycosylated.

CD24

Anti-CD24 antibodies