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CD63

CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Hermansky-Pudlak Syndrome and Melanoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is TSPAN33.
Full Name
CD63 Molecule
Function
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Biological Process
Cell-matrix adhesion Source: UniProtKB
Cell migration Source: UniProtKB
Cellular protein localization Source: MGI
Endosome to melanosome transport Source: UniProtKB
Neutrophil degranulation Source: Reactome
Pigment granule maturation Source: UniProtKB
Platelet degranulation Source: Reactome
Positive regulation of integrin-mediated signaling pathway Source: UniProtKB
Positive regulation of receptor internalization Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of potassium ion transmembrane transport Source: MGI
Regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
Cellular Location
Lysosome membrane; Cell membrane; Extracellular exosome; Late endosome membrane; Multivesicular body; Melanosome; Cell surface. Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Topology
Cytoplasmic: 2-11
Helical: 12-32
Extracellular: 33-51
Helical: 52-72
Cytoplasmic: 73-81
Helical: 82-102
Extracellular: 103-203
Helical: 204-224
Cytoplasmic: 225-238
PTM
Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
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Anti-CD63 antibodies

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Mouse Anti-CD63 Recombinant Antibody (CBXC-1200) (CBMAB-C1467-CQ)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-1200
Application*: WB, IF, IP, E, P
Datasheet SDS

Rat Anti-CD63 Recombinant Antibody (7G4.2E8) (CBMAB-C8725-LY)

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Target: CD63
Host: Rat
Antibody Isotype: IgG2a, λ
Specificity: Mouse, Human
Clone: 7G4.2E8
Application*: WB, F
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (CBT2640) (V2LY-0625-LY881)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2640
Application*: IH, F
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (CBT2326) (V2LY-0625-LY880)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2326
Application*: IH, F
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (LAMP3/529) (CBMAB-AP1200LY)

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Target: CD63
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: LAMP3/529
Application*: WB
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (TEA3/18) (CBMAB-C10552-LY)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TEA3/18
Application*: F
Datasheet SDS

Rabbit Anti-CD63 Recombinant Antibody (CBNH-027) (CBMAB-R4352-CN)

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Target: CD63
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBNH-027
Application*: E
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (NKI/C-3) (CBMAB-C1878-CN)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: NKI/C-3
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (CBXC-2498) (CBMAB-C4192-CQ)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2498
Application*: IH, WB
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (CBXC-2866) (CBMAB-C4191-CQ)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBXC-2866
Application*: F
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (MX-49.129.5) (CBMAB-C0945-CQ)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: MX-49.129.5
Application*: WB, F, IF, IP, E, P
Datasheet SDS

Mouse Anti-CD63 Recombinant Antibody (MEM-259) (CBMAB-C0873-CQ)

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Target: CD63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-259
Application*: F, IF, P, IP
Datasheet SDS

Rabbit Anti-CD63 Recombinant Antibody (142) (CBMAB-C2956-LY)

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Target: CD63
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 142
Application*: E
Datasheet SDS

Rabbit Anti-CD63 Recombinant Antibody (001) (CBMAB-C1455-LY)

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Target: CD63
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 001
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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