CDK5R2

CDK5R2 (Cyclin Dependent Kinase 5 Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of this gene is CDK5R1.

Full Name

Cyclin Dependent Kinase 5 Regulatory Subunit 2

Function

Activator of CDK5/TPKII.

Biological Process

Cerebellum development Source: Ensembl
Hippocampus development Source: Ensembl
Layer formation in cerebral cortex Source: Ensembl
Neuron migration Source: Ensembl
Positive regulation of calcium ion-dependent exocytosis Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Superior olivary nucleus maturation Source: Ensembl

Cellular Location

Cell membrane

PTM

Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).