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Rabbit Anti-CDK5R2 Recombinant Antibody (CBYC-P044) (CBMAB-P0175-YC)

Provided herein is a Rabbit monoclonal antibody against Human Cyclin Dependent Kinase 5 Regulatory Subunit 2. The antibody can be used for immunoassay techniques, such as IHC-P, IP, WB.
See all CDK5R2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYC-P044
Antibody Isotype
IgG
Application
IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to p39
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
50 mM Tris glycine, pH 7.4, 150 mM sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase 5 Regulatory Subunit 2
Introduction
CDK5R2 (Cyclin Dependent Kinase 5 Regulatory Subunit 2) is a protein coding gene. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Reelin Pathway (Cajal-Retzius cells). Gene Ontology annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of the gene is CDK5R1.
Entrez Gene ID
Human8941
Mouse12570
Rat501164
UniProt ID
HumanQ13319
MouseO35926
RatF1M491
Alternative Names
p39nck5ai; P39; NCK5AI
Function
Activator of CDK5/TPKII.
Biological Process
Cerebellum development Source: Ensembl
Hippocampus development Source: Ensembl
Layer formation in cerebral cortex Source: Ensembl
Neuron migration Source: Ensembl
Positive regulation of calcium ion-dependent exocytosis Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Superior olivary nucleus maturation Source: Ensembl
Cellular Location
Cell membrane
PTM
Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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