CELSR2

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Full Name

Cadherin EGF LAG Seven-Pass G-Type Receptor 2

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Biological Process

Cell-cell adhesion Source: GO_Central
Cerebrospinal fluid secretion Source: Ensembl
Cilium assembly Source: Ensembl
Cilium movement Source: Ensembl
Dendrite morphogenesis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Neural plate anterior/posterior regionalization Source: BHF-UCL
Neuron migration Source: Ensembl
Regulation of cell-cell adhesion Source: BHF-UCL
Regulation of protein localization Source: Ensembl
Regulation of transcription, DNA-templated Source: BHF-UCL
Ventricular system development Source: Ensembl
Wnt signaling pathway Source: BHF-UCL
Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 32-2380
Helical: 2381-2401
Cytoplasmic: 2402-2416
Helical: 2417-2437
Extracellular: 2438
Helical: 2439-2459
Cytoplasmic: 2460-2480
Helical: 2481-2501
Extracellular: 2502-2519
Helical: 2520-2540
Cytoplasmic: 2541-2560
Helical: 2561-2581
Extracellular: 2582-2591
Helical: 2592-2612
Cytoplasmic: 2613-2923

PTM

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.