DAB1

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, disabled-1 plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. DAB1 is similar to disabled-1, and DAB1 is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.

Full Name

DAB1, Reelin Adaptor Protein

Function

Adapter molecule functioning in neural development. May regulate SIAH1 activity.

Biological Process

Adult walking behavior Source: Ensembl
Axon guidance Source: Reactome
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Source: Ensembl
Cerebellum structural organization Source: Ensembl
Dendrite development Source: Ensembl
Golgi localization Source: Ensembl
Hippocampus development Source: Ensembl
Lateral motor column neuron migration Source: GO_Central
Midgut development Source: Ensembl
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of axonogenesis Source: Ensembl
Negative regulation of cell adhesion Source: Ensembl
Negative regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of protein kinase activity Source: Ensembl
Radial glia guided migration of Purkinje cell Source: Ensembl
Response to drug Source: Ensembl
Small GTPase mediated signal transduction Source: Ensembl
Ventral spinal cord development Source: GO_Central

Cellular Location

Cytosol; Apical part of cell; Brush border; Cytoplasm; Intracellular membrane-bounded organelle; Membrane; Neuron projection; Neuronal cell body; Perinuclear region of cytoplasm; Postsynaptic density

Involvement in disease

Spinocerebellar ataxia 37 (SCA37):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA37 is an autosomal dominant form characterized by adult-onset of slowly progressive gait instability, frequent falls, and dysarthria associated with cerebellar atrophy on brain imaging.

PTM

Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.