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DBI

DBI is diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors loca

Full Name

Diazepam Binding Inhibitor, Acyl-CoA Binding Protein

Function

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Biological Process

Acyl-CoA metabolic process Source: Reactome
Negative regulation of protein lipidation Source: UniProtKB
Phosphatidylcholine acyl-chain remodeling Source: UniProtKB
Positive regulation of CoA-transferase activity Source: UniProtKB
Positive regulation of phospholipid transport Source: UniProtKB

Cellular Location

Golgi apparatus; Endoplasmic reticulum. Golgi localization is dependent on ligand binding (PubMed:17953517).

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Anti-DBI antibodies

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Mouse Anti-DBI Recombinant Antibody (CBFYE-0351) (V2LY-0125-LY1147)

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Target: DBI

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYE-0351

Application*: WB, IP, IF, E

Rabbit Anti-DBI Recombinant Antibody (20B10) (V2LY-0125-LY1146)

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Target: DBI

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 20B10

Application*: E, WB

Mouse Anti-DBI Recombinant Antibody (10K186) (V2LY-0125-LY1145)

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Target: DBI

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat, Pig

Clone: 10K186

Application*: IH, IF, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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