EEF1E1

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Full Name
Eukaryotic Translation Elongation Factor 1 Epsilon 1
Research Area
Positive modulator of ATM response to DNA damage.
Biological Process
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cellular senescence Source: BHF-UCL
Positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Translation Source: UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm; Cytosol. Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.
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Anti-EEF1E1 antibodies

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Mouse Anti-EEF1E1 Recombinant Antibody (CAP662) (CBMAB-AP1986LY)

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Target: EEF1E1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CAP662
Application*: FC, IF, WB
Datasheet SDS

Recombinant Mouse Anti-EEF1E1 Antibody (CBAb091) (CBMAB-Ab091-LY)

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Target: EEF1E1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBAb091
Application*: WB, IF, FC
Datasheet SDS

Mouse Anti-EEF1E1 Recombinant Antibody (CAP662) (V2LY-0425-LY1458)

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Target: EEF1E1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CAP662
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-EEF1E1 Recombinant Antibody (CBAb091) (V2LY-0425-LY1457)

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Target: EEF1E1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBAb091
Application*: WB, IF, F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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