EEF1E1

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

Eukaryotic Translation Elongation Factor 1 Epsilon 1

Positive modulator of ATM response to DNA damage.

Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cellular senescence Source: BHF-UCL
Positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Translation Source: UniProtKB-KW

Nucleus; Cytoplasm; Cytosol. Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.