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EEF1E1

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

Full Name

Eukaryotic Translation Elongation Factor 1 Epsilon 1

Research Area

Positive modulator of ATM response to DNA damage.

Biological Process

Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cellular senescence Source: BHF-UCL
Positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Translation Source: UniProtKB-KW

Cellular Location

Nucleus; Cytoplasm; Cytosol. Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.

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Anti-EEF1E1 antibodies

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Mouse Anti-EEF1E1 Recombinant Antibody (CAP662) (CBMAB-AP1986LY)

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Target: EEF1E1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CAP662

Application*: FC, IF, WB

Recombinant Mouse Anti-EEF1E1 Antibody (CBAb091) (CBMAB-Ab091-LY)

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Target: EEF1E1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBAb091

Application*: WB, IF, FC

Human Recombinant EEF1E1 protein, His Tag (V2LY-0526-LY3691)

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Target: EEF1E1

Expressed Host: E. coli

Sequence: Amino Acid: 1-174

Tag: His Tag

Mouse Anti-EEF1E1 Recombinant Antibody (CAP662) (V2LY-0425-LY1458)

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Target: EEF1E1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig

Clone: CAP662

Application*: WB, IP, IF, E, P

Mouse Anti-EEF1E1 Recombinant Antibody (CBAb091) (V2LY-0425-LY1457)

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Target: EEF1E1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: CBAb091

Application*: WB, IF, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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