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Mouse Anti-EEF1E1 Recombinant Antibody (CAP662) (CBMAB-AP1986LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CAP662
Antibody Isotype
IgG
Application
FC, IF, WB

Basic Information

Immunogen
A synthetic peptide of human EEF1E1
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Eukaryotic Translation Elongation Factor 1 Epsilon 1
Introduction
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Entrez Gene ID
Human9521
Mouse66143
UniProt ID
HumanO43324
MouseQ9D1M4
Alternative Names
Eukaryotic Translation Elongation Factor 1 Epsilon 1; Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 3; Multisynthase Complex Auxiliary Component P18; AIMP3; P18; Eukaryotic Translation Elongation Factor 1 Epsilon-1; P18 Component Of Aminoacyl-TRNA Synthetase Complex; ARS-Interacting Multifunctional Protein 3; Elongation Factor P18;
Research Area
Positive modulator of ATM response to DNA damage.
Biological Process
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cellular senescence Source: BHF-UCL
Positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Translation Source: UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm; Cytosol. Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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