EID3

EID3 (EP300 Interacting Inhibitor Of Differentiation 3) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is NSMCE4A.

Full Name

EP300 interacting inhibitor of differentiation 3

Research Area

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.

Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

Biological Process

DNA recombination Source: UniProtKB-KW
DNA repair Source: GO_Central

Cellular Location

Nucleus; Cytoplasm; Telomere. May shuttle between nucleus and cytoplasm.