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EIF5

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]
Full Name
Eukaryotic Translation Initiation Factor 5
Research Area
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
Biological Process
Activation of GTPase activity Source: Ensembl
Formation of cytoplasmic translation initiation complex Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: CACAO
Cellular Location
Cytosol; Plasma membrane; Cytoplasm
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Anti-EIF5 antibodies

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Mouse Anti-EIF5 Recombinant Antibody (CP0572) (V2LY-0825-LY4)

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Target: EIF5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CP0572
Application*: WB, IF, E, P
Datasheet SDS

Mouse Anti-EIF5 Recombinant Antibody (A2551) (V2LY-0825-LY3)

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Target: EIF5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: A2551
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-EIF5 Recombinant Antibody (CBFYE-0190) (V2LY-0825-LY2)

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Target: EIF5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0190
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EIF5 Recombinant Antibody (E1180) (V2LY-0825-LY1)

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Target: EIF5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: E1180
Application*: F, WB, IF
Datasheet SDS

Mouse Anti-EIF5 Recombinant Antibody (CBT4053) (V2LY-0625-LY553)

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Target: EIF5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4053
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-EIF5 Recombinant Antibody (CBT4715) (V2LY-0625-LY552)

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Target: EIF5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBT4715
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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