EMD

Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
Full Name
emerin
Research Area
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Biological Process
Cellular response to growth factor stimulus Source: BHF-UCL
Muscle contraction Source: ProtInc
Muscle organ development Source: ProtInc
Negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Negative regulation of fibroblast proliferation Source: BHF-UCL
Nuclear membrane organization Source: FlyBase
Positive regulation of protein export from nucleus Source: BHF-UCL
Regulation of canonical Wnt signaling pathway Source: BHF-UCL
Skeletal muscle cell differentiation Source: Ensembl
Cellular Location
Nucleus inner membrane; Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
Involvement in disease
Emery-Dreifuss muscular dystrophy 1, X-linked (EDMD1):
A form of Emery-Dreifuss muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
Topology
Helical: 223-243
PTM
Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
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Anti-EMD antibodies

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Mouse Anti-EMD Recombinant Antibody (39) (CBMAB-A2581-LY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 39
Application*: IP, IF, WB
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (19) (CBMAB-1199CQ)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 19
Application*: WB, IP
Datasheet SDS

Mouse Anti-EMD Monoclonal Antibody (2D6) (CBMAB-1198CQ)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D6
Application*: WB, IF
Datasheet SDS

Mouse Anti-EMD Monoclonal Antibody (5D10) (CBMAB-1197CQ)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D10
Application*: IF
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (CBFYE-0820) (V2LY-0825-LY156)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0820
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-EMD Recombinant Antibody (E1268) (V2LY-0825-LY152)

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Target: EMD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E1268
Application*: WB, F, IF, IH
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (CBT2719) (V2LY-0625-LY316)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2719
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (CBT4052) (V2LY-0625-LY315)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4052
Application*: IC, F
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (16) (CBMAB-BR168LY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 16
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (510) (CBMAB-BR167LY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 510
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (CBFYE-0819) (CBMAB-E1271-FY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0819
Application*: WB, IH, IF, E
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (CBFYE-0816) (CBMAB-E1266-FY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0816
Application*: IP, IF, WB
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (CBFYE-0205) (CBMAB-E0453-FY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0205
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EMD Recombinant Antibody (26) (CBMAB-E1267-FY)

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Target: EMD
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 26
Application*: WB, IP, IF, E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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