FEM1A

FEM1A (Fem-1 Homolog A) is a Protein Coding gene. Diseases associated with FEM1A include Rhabdomyosarcoma. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and EP4 subtype prostaglandin E2 receptor binding. An important paralog of this gene is FEM1C.

Full Name

Fem-1 Homolog A

Research Area

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170).

The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170).

The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170).

Promotes ubiquitination and degradation of SLBP (PubMed:28118078).

Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity).

Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity).

Biological Process

Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of inflammatory response Source: UniProtKB
Regulation of ubiquitin-protein transferase activity Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: GO_Central
Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway Source: UniProtKB

Cellular Location

Mitochondrion; Cytoplasm

PTM

Phosphorylated; highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 promotes PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A).By similarity