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FGF12

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Full Name
Fibroblast Growth Factor 12
Research Area
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Biological Process
Adult locomotory behavior Source: Ensembl
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cell-cell signaling Source: ProtInc
Chemical synaptic transmission Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: InterPro
Heart development Source: ProtInc
JNK cascade Source: MGI
Negative regulation of cation channel activity Source: Ensembl
Nervous system development Source: ProtInc
Neuromuscular process Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Regulation of membrane depolarization Source: Ensembl
Regulation of neuronal action potential Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Developmental and epileptic encephalopathy 47 (DEE47):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
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Anti-FGF12 antibodies

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Mouse Anti-FGF12 Recombinant Antibody (610) (CBMAB-AP2261LY)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 610
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CF166) (CBMAB-FT316LY)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF166
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (1D9) (CBMAB-A2929-LY)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D9
Application*: WB, E
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-0542) (CBMAB-F3168-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0542
Application*: SE, E, WB, P
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-0537) (CBMAB-F2669-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0537
Application*: E, WB
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-0541) (CBMAB-F1441-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0541
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-0540) (CBMAB-F1222-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXF-0540
Application*: WB, P, PE
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-0538) (CBMAB-F1221-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-0538
Application*: IF
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-2259) (CBMAB-F1147-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2259
Application*: E, WB
Datasheet SDS

Mouse Anti-FGF12 Recombinant Antibody (CBXF-0539) (CBMAB-F0859-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0539
Application*: WB, P
Datasheet SDS

Mouse Anti-FGF12 (AA 1-182) Recombinant Antibody (CBXF-0536) (CBMAB-F0290-CQ)

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Target: FGF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0536
Application*: E, IH, WB
Datasheet SDS

FGF12 Matched Antibody Pair (430) (APMAB-430LY)

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Target: FGF12
Specificity: Human
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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