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Mouse Anti-FGF12 Recombinant Antibody (CBXF-0540) (CBMAB-F1222-CQ)

This product is a mouse antibody that recognizes FGF12. The antibody CBXF-0540 can be used for immunoassay techniques such as: WB, IHC-P, P-ELISA.
See all FGF12 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXF-0540
Antibody Isotype
IgG
Application
WB, IHC-P, P-ELISA

Basic Information

Immunogen
Synthetic peptide
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM PBS, pH 7.4, 10 mg/ml BSA, 25% glycerol
Preservative
0.03% Proclin 300
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor 12
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Entrez Gene ID
Human2257
Rat170630
UniProt ID
HumanP61328
RatP61150
Alternative Names
Fibroblast Growth Factor 12; Fibroblast Growth Factor Homologous Factor 1; Myocyte-Activating Factor; Fibroblast Growth Factor FGF-12b; Fibroblast Growth Factor 12B; FGF12B;
Research Area
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Biological Process
Adult locomotory behavior Source: Ensembl
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cell-cell signaling Source: ProtInc
Chemical synaptic transmission Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: InterPro
Heart development Source: ProtInc
JNK cascade Source: MGI
Negative regulation of cation channel activity Source: Ensembl
Nervous system development Source: ProtInc
Neuromuscular process Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Regulation of membrane depolarization Source: Ensembl
Regulation of neuronal action potential Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Developmental and epileptic encephalopathy 47 (DEE47):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Woo, J., Suh, W., & Sung, J. H. (2022). Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Sciences, 23(16), 9467.

Liu, A., Zhang, Y., Xun, S., Zhou, G., Lin, L., & Mei, Y. (2022). Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress. Peptides, 153, 170786.

Gao, X., Liao, Z., Su, R., Zheng, D., Huang, G., Huang, Z., & Cheng, X. (2022). Depletion of Fibroblast Growth Factor 12 Restrains the Viability, Stemness, and Motility of Colorectal Cancer. BioMed Research International, 2022.

Zhou, M., Chen, J., Meng, K., Zhang, Y., Zhang, M., Lu, P., ... & Tian, H. (2021). Production of bioactive recombinant human fibroblast growth factor 12 using a new transient expression vector in E. coli and its neuroprotective effects. Applied Microbiology and Biotechnology, 105(13), 5419-5431.

Yeo, Y., Yi, E. S., Kim, J. M., Jo, E. K., Seo, S., Kim, R. I., ... & Suh, W. (2020). FGF12 (fibroblast growth factor 12) inhibits vascular smooth muscle cell remodeling in pulmonary arterial hypertension. Hypertension, 76(6), 1778-1786.

Wu, J., Huang, H., Huang, Q., Qiu, R., Huang, M., & Meng, D. (2020). A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma. Cytokine, 136, 155294.

Hanada, Y., Nakamura, Y., Ozono, Y., Ishida, Y., Takimoto, Y., Taniguchi, M., ... & Shimada, S. (2018). Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Scientific reports, 8(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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