Sign in or Register   Sign in or Register
  |  

Mouse Anti-FGF12 Recombinant Antibody (1D9) (CBMAB-A2929-LY)

The product is antibody recognizes FGF12. The antibody 1D9 immunoassay techniques such as: WB, ELISA.
See all FGF12 antibodies
Published Data
Fig.1 Expression of FGF12 in KYSE410 ESCC cell line.
...View More
Fig.2 Effect of reduction of FGF12 on ESCC cell progression in KYSE410 cells.
...View More
Fig.3 Immunohistochemical staining of FGF12 in ESCC tissue.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
FGF12 (AAH22524, 1 a.a. ~ 181 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fibroblast Growth Factor 12
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Entrez Gene ID
2257
UniProt ID
P61328
Alternative Names
FGF12B; FHF1
Research Area
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Biological Process
Adult locomotory behavior Source: Ensembl
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cell-cell signaling Source: ProtInc
Chemical synaptic transmission Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: InterPro
Heart development Source: ProtInc
JNK cascade Source: MGI
Negative regulation of cation channel activity Source: Ensembl
Nervous system development Source: ProtInc
Neuromuscular process Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Regulation of membrane depolarization Source: Ensembl
Regulation of neuronal action potential Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Developmental and epileptic encephalopathy 47 (DEE47):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Woo, J., Suh, W., & Sung, J. H. (2022). Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Sciences, 23(16), 9467.

Liu, A., Zhang, Y., Xun, S., Zhou, G., Lin, L., & Mei, Y. (2022). Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress. Peptides, 153, 170786.

Gao, X., Liao, Z., Su, R., Zheng, D., Huang, G., Huang, Z., & Cheng, X. (2022). Depletion of Fibroblast Growth Factor 12 Restrains the Viability, Stemness, and Motility of Colorectal Cancer. BioMed Research International, 2022.

Zhou, M., Chen, J., Meng, K., Zhang, Y., Zhang, M., Lu, P., ... & Tian, H. (2021). Production of bioactive recombinant human fibroblast growth factor 12 using a new transient expression vector in E. coli and its neuroprotective effects. Applied Microbiology and Biotechnology, 105(13), 5419-5431.

Yeo, Y., Yi, E. S., Kim, J. M., Jo, E. K., Seo, S., Kim, R. I., ... & Suh, W. (2020). FGF12 (fibroblast growth factor 12) inhibits vascular smooth muscle cell remodeling in pulmonary arterial hypertension. Hypertension, 76(6), 1778-1786.

Wu, J., Huang, H., Huang, Q., Qiu, R., Huang, M., & Meng, D. (2020). A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma. Cytokine, 136, 155294.

Hanada, Y., Nakamura, Y., Ozono, Y., Ishida, Y., Takimoto, Y., Taniguchi, M., ... & Shimada, S. (2018). Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Scientific reports, 8(1), 1-10.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FGF12 Recombinant Antibody (1D9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare