Mouse Anti-FGF12 Recombinant Antibody (CBXF-0538) (CBMAB-F1221-CQ)

Name: Mouse Anti-FGF12 Recombinant Antibody (CBXF-0538)
SKU: CBMAB-F1221-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0538

Application

Immunogen

Synthetic peptide

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10 mM PBS, pH 7.4, 10 mg/ml BSA, 25% glycerol

Preservative

0.03% Proclin 300

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 12

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

Entrez Gene ID

Human	2257
Mouse	14167
Rat	170630

UniProt ID

Human	P61328
Mouse	P61329
Rat	P61150

Alternative Names

Fibroblast Growth Factor 12; Fibroblast Growth Factor Homologous Factor 1; Myocyte-Activating Factor; Fibroblast Growth Factor FGF-12b; Fibroblast Growth Factor 12B; FGF12B;

Research Area

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.

Biological Process

Adult locomotory behavior Source: Ensembl
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cell-cell signaling Source: ProtInc
Chemical synaptic transmission Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: InterPro
Heart development Source: ProtInc
JNK cascade Source: MGI
Negative regulation of cation channel activity Source: Ensembl
Nervous system development Source: ProtInc
Neuromuscular process Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Regulation of membrane depolarization Source: Ensembl
Regulation of neuronal action potential Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Developmental and epileptic encephalopathy 47 (DEE47):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Woo, J., Suh, W., & Sung, J. H. (2022). Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Sciences, 23(16), 9467.

Liu, A., Zhang, Y., Xun, S., Zhou, G., Lin, L., & Mei, Y. (2022). Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress. Peptides, 153, 170786.

Gao, X., Liao, Z., Su, R., Zheng, D., Huang, G., Huang, Z., & Cheng, X. (2022). Depletion of Fibroblast Growth Factor 12 Restrains the Viability, Stemness, and Motility of Colorectal Cancer. BioMed Research International, 2022.

Zhou, M., Chen, J., Meng, K., Zhang, Y., Zhang, M., Lu, P., ... & Tian, H. (2021). Production of bioactive recombinant human fibroblast growth factor 12 using a new transient expression vector in E. coli and its neuroprotective effects. Applied Microbiology and Biotechnology, 105(13), 5419-5431.

Yeo, Y., Yi, E. S., Kim, J. M., Jo, E. K., Seo, S., Kim, R. I., ... & Suh, W. (2020). FGF12 (fibroblast growth factor 12) inhibits vascular smooth muscle cell remodeling in pulmonary arterial hypertension. Hypertension, 76(6), 1778-1786.

Wu, J., Huang, H., Huang, Q., Qiu, R., Huang, M., & Meng, D. (2020). A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma. Cytokine, 136, 155294.

Hanada, Y., Nakamura, Y., Ozono, Y., Ishida, Y., Takimoto, Y., Taniguchi, M., ... & Shimada, S. (2018). Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Scientific reports, 8(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

FGF12 Matched Antibody Pair (430) (CAT#: APMAB-430LY)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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