GAL3ST1

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq]

Full Name

galactose-3-O-sulfotransferase 1

Function

Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids (PubMed:9030544, PubMed:8830034).

Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (PubMed:8830034).

Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety (PubMed:8830034).

Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (PubMed:8830034).

Biological Process

Galactosylceramide biosynthetic process Source: GO_Central
Galactosylceramide metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: UniProtKB
Myelination Source: GO_Central
Protein N-linked glycosylation Source: ProtInc
Spermatogenesis Source: Ensembl
Sphingolipid metabolic process Source: UniProtKB

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-14
Helical: 15-35
Lumenal: 36-423