Mouse Anti-GAL3ST1 Recombinant Antibody (CBCNC-604) (CBMAB-C3519-CN)

Name: Mouse Anti-GAL3ST1 Recombinant Antibody (CBCNC-604)
SKU: CBMAB-C3519-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBCNC-604

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

galactose-3-O-sulfotransferase 1

Introduction

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Entrez Gene ID

9514

UniProt ID

Q99999

Alternative Names

Galactose-3-O-Sulfotransferase 1; 3-Phosphoadenosine-5-Phosphosulfate:GalCer Sulfotransferase; CST; Cerebroside (3 Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase; Cerebroside (3-Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase; 3-Phosphoadenylylsulfate:Galactosylceramide 3-Sulfotransferase;

Function

Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids (PubMed:9030544, PubMed:8830034).

Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (PubMed:8830034).

Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety (PubMed:8830034).

Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (PubMed:8830034).

Biological Process

Galactosylceramide biosynthetic process Source: GO_Central
Galactosylceramide metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: UniProtKB
Myelination Source: GO_Central
Protein N-linked glycosylation Source: ProtInc
Spermatogenesis Source: Ensembl
Sphingolipid metabolic process Source: UniProtKB

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-14
Helical: 15-35
Lumenal: 36-423

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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