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Mouse Anti-GAL3ST1 Recombinant Antibody (CBCNC-604) (CBMAB-C3519-CN)

This product is a Mouse antibody that recognizes GAL3ST1. The antibody CBCNC-604 can be used for immunoassay techniques such as: ELISA, WB.
See all GAL3ST1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-604
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2

Target

Full Name
galactose-3-O-sulfotransferase 1
Introduction
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Entrez Gene ID
UniProt ID
Alternative Names
Galactose-3-O-Sulfotransferase 1; 3-Phosphoadenosine-5-Phosphosulfate:GalCer Sulfotransferase; CST; Cerebroside (3 Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase; Cerebroside (3-Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase; 3-Phosphoadenylylsulfate:Galactosylceramide 3-Sulfotransferase;
Function
Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids (PubMed:9030544, PubMed:8830034).

Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (PubMed:8830034).

Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety (PubMed:8830034).

Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (PubMed:8830034).
Biological Process
Galactosylceramide biosynthetic process Source: GO_Central
Galactosylceramide metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: UniProtKB
Myelination Source: GO_Central
Protein N-linked glycosylation Source: ProtInc
Spermatogenesis Source: Ensembl
Sphingolipid metabolic process Source: UniProtKB
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-14
Helical: 15-35
Lumenal: 36-423
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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