GAST

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
Full Name
Gastrin
Function
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Biological Process
G protein-coupled receptor signaling pathway Source: GO_Central
Response to food Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
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Anti-GAST antibodies

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Mouse Anti-GAST Recombinant Antibody (CBLG1-657) (CBMAB-G2171-LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-657
Application*: WB
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (G52C7.1) (CBMAB-G2166-LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G52C7.1
Application*: E, P
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (AS1A17) (CBMAB-AP2471LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: AS1A17
Application*: IHC
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (404) (CBMAB-AP2470LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 404
Application*: ELISA, IHC
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (139) (CBMAB-AP2469LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG2c, κ
Specificity: Human
Clone: 139
Application*: E
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (CAP816) (CBMAB-AP2468LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CAP816
Application*: E
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (CBLG1-658) (CBMAB-G2172-LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-658
Application*: WB
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (4C7A1) (CBMAB-G2164-LY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C7A1
Application*: IH
Datasheet SDS

Mouse Anti-GAST (AA 1-101) Recombinant Antibody (CBFYH-0246) (CBMAB-H1116-FY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0246
Application*: E, WB
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (CBFYH-2965) (CBMAB-H1114-FY)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2965
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-GAST Recombinant Antibody (CBLG1-657) (V2LY-1225-LY717)

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Target: GAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-657
Application*: E, P
Datasheet SDS

Human Anti-GAST Recombinant Antibody (G2164) (V2LY-1225-LY715)

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Target: GAST
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: G2164
Application*: E, F, in vivo
In Vivo Assay
Datasheet SDS

Rabbit Anti-GAST Recombinant Antibody (CBFYH-0246) (V2LY-1225-LY714)

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Target: GAST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0246
Application*: IF, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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