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GATB

GATB (Glutamyl-TRNA Amidotransferase Subunit B) is a protein coding gene. Among its related pathways are tRNA Aminoacylation and Metabolism. Gene Ontology annotations related to this gene include ligase activity and translation factor activity, RNA binding.

Full Name

Glutamyl-TRNA Amidotransferase Subunit B

Function

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Biological Process

Glutaminyl-tRNAGln biosynthesis via transamidation Source: UniProtKB
Mitochondrial translation Source: UniProtKB

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 41 (COXPD41):
An autosomal recessive mitochondrial disorder characterized by prenatal onset, fetal hydrops, intrauterine growth retardation, hypertrophic cardiomyopathy, respiratory insufficiency, lactic acidosis, and decreased activities of mitochondrial respiratory complexes I, III, IV, and V. The disorder is lethal, with death occurring in the perinatal period.

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Anti-GATB antibodies

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Mouse Anti-GATB Recombinant Antibody (CBLG1-046) (V2LY-1225-LY789)

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Target: GATB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-046

Application*: E, WB, IP

Mouse Anti-GATB Recombinant Antibody (6B2) (CBMAB-A6577-LY)

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Target: GATB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6B2

Application*: WB, E

Mouse Anti-GATB Recombinant Antibody (CBLG1-046) (CBMAB-G0240-LY)

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Target: GATB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-046

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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