GJB5

This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]

Full Name

Gap Junction Protein Beta 5

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Biological Process

Cell-cell signaling Source: GO_Central
Epidermis development Source: ProtInc
Epididymis development Source: Ensembl
Labyrinthine layer morphogenesis Source: Ensembl
Spongiotrophoblast differentiation Source: Ensembl
Trophoblast giant cell differentiation Source: Ensembl

Cellular Location

Cell membrane; Gap junction

Topology

Cytoplasmic: 1-20
Helical: 21-40
Extracellular: 41-75
Helical: 76-98
Cytoplasmic: 99-126
Helical: 127-149
Extracellular: 150-187
Helical: 188-210
Cytoplasmic: 211-273