GPD1

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Full Name

glycerol-3-phosphate dehydrogenase 1 (soluble)

Function

Has glycerol-3-phosphate dehydrogenase activity.

Biological Process

Cellular response to cAMP Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Gluconeogenesis Source: Ensembl
Glycerol-3-phosphate catabolic process Source: InterPro
Glycerol-3-phosphate metabolic process Source: GO_Central
Glycerolipid metabolic process Source: Ensembl
Glycerophosphate shuttle Source: Ensembl
NADH oxidation Source: GO_Central
Positive regulation of glycolytic process Source: Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Hypertriglyceridemia, transient infantile (HTGTI):
An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis.