Mouse Anti-GPD1 Recombinant Antibody (7H114) (CBMAB-G4529-LY)

Go to compare Compare Online Inquiry
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
7H114
Application
ELISA
Immunogen
Recombinant Human GPD1.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Introduction
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
Entrez Gene ID
UniProt ID
Alternative Names
Glypican 6; Glypican Proteoglycan 6; Glypican-6; OMIMD1;
Function
Has glycerol-3-phosphate dehydrogenase activity.
Biological Process
Cellular response to cAMP Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Gluconeogenesis Source: Ensembl
Glycerol-3-phosphate catabolic process Source: InterPro
Glycerol-3-phosphate metabolic process Source: GO_Central
Glycerolipid metabolic process Source: Ensembl
Glycerophosphate shuttle Source: Ensembl
NADH oxidation Source: GO_Central
Positive regulation of glycolytic process Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Hypertriglyceridemia, transient infantile (HTGTI):
An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis.

Pallapati, A. R., Prasad, S., & Roy, I. (2022). Glycerol 3-phosphate dehydrogenase regulates heat shock response in Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1869(5), 119238.

Luo, Z., Chen, Z., Zhu, Z., Hao, Y., Feng, J., Luo, Q., ... & Ding, G. (2022). Angiotensin II induces podocyte metabolic reprogramming from glycolysis to glycerol-3-phosphate biosynthesis. Cellular Signalling, 99, 110443.

Karaosmanoglu Yoneten, K., Kasap, M., Arga, K. Y., Akpinar, G., & Utkan, N. Z. (2022). Decreased serum levels of glycerol-3-phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer. Cancer Biomarkers, 34(1), 67-76.

Pallapati, A. R., Sirigiri, S. D., Jain, S., Ratnala, V., & Roy, I. (2021). Lysine245 plays a crucial role in stability and function of glycerol 3‐phosphate dehydrogenase (Gpd1) in Saccharomyces cerevisiae. Journal of Cellular Biochemistry, 122(11), 1726-1736.

Matarazzo, L., Ragnoni, V., Malaventura, C., Leon, A., Colavito, D., Vigna, G. B., ... & Maggiore, G. (2020). Successful fenofibrate therapy for severe and persistent hypertriglyceridemia in a boy with cirrhosis and glycerol‐3‐phosphate dehydrogenase 1 deficiency. JIMD reports, 54(1), 25-31.

Yoneten, K. K., Kasap, M., Akpinar, G., Gunes, A., Gurel, B., & Utkan, N. Z. (2019). Comparative proteome analysis of breast cancer tissues highlights the importance of glycerol-3-phosphate dehydrogenase 1 and monoacylglycerol lipase in breast cancer metabolism. Cancer Genomics & Proteomics, 16(5), 377-397.

Lee, J., & Levin, D. E. (2019). Methylated metabolite of arsenite blocks glycerol production in yeast by inhibition of glycerol-3-phosphate dehydrogenase. Molecular Biology of the Cell, 30(17), 2134-2140.

Chhikara, S., Abdullah, H. M., Akbari, P., Schnell, D., & Dhankher, O. P. (2018). Engineering Camelina sativa (L.) Crantz for enhanced oil and seed yields by combining diacylglycerol acyltransferase1 and glycerol‐3‐phosphate dehydrogenase expression. Plant biotechnology journal, 16(5), 1034-1045.

Li, J. Q., Xie, X. B., Feng, J. Y., Chen, L., Abuduxikuer, K., Lu, Y., ... & Wang, J. S. (2018). A novel homozygous mutation in the glycerol-3-phosphate dehydrogenase 1 gene in a Chinese patient with transient infantile hypertriglyceridemia: a case report. BMC gastroenterology, 18(1), 1-8.

Mojardín, L., Vega, M., Moreno, F., Schmitz, H. P., Heinisch, J. J., & Rodicio, R. (2018). Lack of the NAD+-dependent glycerol 3-phosphate dehydrogenase impairs the function of transcription factors Sip4 and Cat8 required for ethanol utilization in Kluyveromyces lactis. Fungal Genetics and Biology, 111, 16-29.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-GPD1 Recombinant Antibody (7H114)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.