HES1

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

HES1

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity).

May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Adenohypophysis development Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Artery morphogenesis Source: BHF-UCL
Ascending aorta morphogenesis Source: BHF-UCL
Cardiac neural crest cell development involved in outflow tract morphogenesis Source: Ensembl
Cell adhesion Source: Ensembl
Cell maturation Source: Ensembl
Cell migration Source: Ensembl
Cell morphogenesis involved in neuron differentiation Source: Ensembl
Cellular response to fatty acid Source: Ensembl
Cellular response to interleukin-1 Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Cochlea development Source: Ensembl
Comma-shaped body morphogenesis Source: Ensembl
Common bile duct development Source: Ensembl
Embryonic heart tube morphogenesis Source: BHF-UCL
Establishment of epithelial cell polarity Source: Ensembl
Forebrain radial glial cell differentiation Source: UniProtKB
Glomerulus vasculature development Source: Ensembl
Hair cell differentiation Source: Ensembl
Hindbrain morphogenesis Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Labyrinthine layer blood vessel development Source: Ensembl
Lateral inhibition Source: Ensembl
Liver development Source: Ensembl
Lung development Source: Ensembl
Metanephric nephron tubule morphogenesis Source: Ensembl
Midbrain development Source: Ensembl
Midbrain-hindbrain boundary morphogenesis Source: Ensembl
Negative regulation of calcium ion import Source: Ensembl
Negative regulation of cell fate determination Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
Negative regulation of forebrain neuron differentiation Source: UniProtKB
Negative regulation of gene expression Source: Ensembl
Negative regulation of glial cell proliferation Source: UniProtKB
Negative regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: GO_Central
Negative regulation of neuron projection development Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: UniProtKB
Negative regulation of pancreatic A cell differentiation Source: Ensembl
Negative regulation of pro-B cell differentiation Source: UniProtKB
Negative regulation of stem cell differentiation Source: UniProtKB
Negative regulation of stomach neuroendocrine cell differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Nervous system development Source: ProtInc
Neuronal stem cell population maintenance Source: UniProtKB
Notch signaling pathway Source: UniProtKB
Oculomotor nerve development Source: Ensembl
Outflow tract morphogenesis Source: BHF-UCL
Pancreas development Source: Ensembl
Pharyngeal arch artery morphogenesis Source: BHF-UCL
Positive regulation of astrocyte differentiation Source: UniProtKB
Positive regulation of BMP signaling pathway Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of DNA binding Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Positive regulation of mitotic cell cycle, embryonic Source: BHF-UCL
Positive regulation of Notch signaling pathway Source: Ensembl
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Positive regulation of T cell proliferation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Protein-containing complex assembly Source: UniProtKB
Regulation of epithelial cell proliferation Source: Ensembl
Regulation of fat cell differentiation Source: Ensembl
Regulation of neurogenesis Source: GO_Central
Regulation of protein-containing complex assembly Source: Ensembl
Regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Regulation of secondary heart field cardioblast proliferation Source: Ensembl
Regulation of timing of neuron differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Renal interstitial fibroblast development Source: Ensembl
Response to alkaloid Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to thyroid hormone Source: Ensembl
Smoothened signaling pathway Source: Ensembl
Somatic stem cell population maintenance Source: Ensembl
S-shaped body morphogenesis Source: Ensembl
Telencephalon development Source: Ensembl
Thymus development Source: BHF-UCL
Trochlear nerve development Source: Ensembl
Ureteric bud morphogenesis Source: Ensembl
Vascular associated smooth muscle cell development Source: BHF-UCL
Ventricular septum development Source: BHF-UCL
Ventricular septum morphogenesis Source: BHF-UCL

Nucleus